Adipotide is a synthetic peptide that is primarily being studied as a potential treatment for obesity and metabolic diseases. It is thought to be a peptide compound that can promote fat metabolism and reduce body fat.

How does Adipotide work?

Adipotide is an investigational drug primarily used to promote fat loss and weight management. It is a peptide drug that reduces fat by affecting the function of fat cells. Here's a detailed look at how Adipotide works and how it works:

Mechanism overview

Targeting fat cells: Adipotide primarily acts on fat cells, especially white fat cells. It affects survival and function by binding to specific receptors on the surface of fat cells.

Pro-apoptotic effect: Adipotide promotes apoptosis (programmed cell death) of fat cells, thereby reducing fat storage in the body. This process works by inhibiting signaling pathways associated with fat cell survival.

Activation of lipolysis: Adipotide may also promote lipolysis of fat cells, which is the release of stored fat into the bloodstream for energy metabolism.

Action mechanism

Binding receptors: The peptide chain of Adipotide contains a specific sequence of amino acids that can selectively bind to the receptors of fat cells, and this binding triggers a series of intracellular signal transduction reactions.

Influence energy metabolism: By regulating the survival and apoptosis of fat cells, Adipotide can affect the energy balance of the whole body, prompting the body to use stored fat more efficiently as an energy source.

Reducing appetite: Some studies suggest that Adipotide may also have an appetite suppressing effect, further aiding weight management.

Potential effect

Fat loss: Adipotide has shown significant fat loss in animal models, especially in terms of abdominal fat loss.

Weight management: By reducing the number of fat cells and fat storage in the body, Adipotide can help control weight and improve obesity-related metabolic diseases (such as type 2 diabetes, high blood pressure, etc.).

Research and clinical trials

Animal studies: Earlier studies focused on mouse models showed that Adipotide was able to significantly reduce body weight and body fat.

Clinical trials: Although some positive results have been achieved in animal models, research in humans is still preliminary and more clinical trials are needed to verify its safety and efficacy.

Safety and side effects

Potential side effects: Due to the pro-apoptotic effect of Adipotide, long-term use may cause irreversible damage to adipotide cells, thereby affecting normal metabolic function.

Unknown risks: Because current research on Adipotide is still in its early stages, its long-term safety and potential side effects are not fully understood.

What is the best way to use Adipotide?

Adipotide (FTPP) is an investigational peptide compound that promotes fat loss by disrupting the vascular supply of adipose tissue. Some common uses and considerations include:

Route of administration

injection: Adipotide is usually administered by subcutaneous injection. The injection site is usually selected in an area with a lot of subcutaneous fat, such as the abdomen.

Dose

There is no official recommended dose, and the doses used in studies are usually adjusted based on body weight and experimental models. For example, in animal experiments, the dose is generally 1-10 mg/kg per day.

Course of treatment

In animal studies, Adipotide typically lasts from a few weeks to a few months.

How does Adipotide compare to other weight loss drugs?

Adipotide (FTPP) has some unique advantages over other weight loss drugs, but it also has its limitations. As an experimental compound, it differs significantly in mechanism and action from traditional weight loss drugs such as GLP-1 class drugs (such as Semaglutide) or oral fat absorption inhibitors (such as Orlistat).

Benefits of Adipotide:

It targets the blood vessels of adipose tissue

Unique mechanism: Adipotide has a different mechanism of action than common weight loss drugs. It destroys blood vessels in fat tissue, depriving fat cells of their nutrient supply and eventually leading to fat cell death. This is a pathway that directly targets fat cells, rather than by affecting appetite or energy metabolism.

Possible faster fat loss: In animal studies, Adipotide has shown faster fat loss, especially on abdominal fat, and may be more effective than drugs that suppress appetite to lose weight.

No need to suppress appetite or change eating habits

Unlike GLP-1 drugs such as Semaglutide, Adipotide does not rely on reducing appetite to achieve weight loss. This may be an advantage for individuals who cannot tolerate long-term appetite suppression.

Local fat reduction potential

Studies of Adipotide in animal models suggest that it may have better targeting of local fat, especially abdominal fat. General weight loss drugs often lead to a reduction in body fat and cannot target specific areas.

May be suitable for obesity or topical stubborn fat

Adipotide may be particularly suitable for individuals who have difficulty reducing fat through regular diet and exercise, especially targeting stubborn fat accumulation areas such as the abdomen, buttocks or thighs.

Comparison with other weight loss drugs:

GLP-1 drugs (such as Semaglutide and Liraglutide)

GLP-1 drugs help weight loss by suppressing appetite and delaying gastric empty. GLP-1 drugs have a broad basis of use and have clear safety data in clinical practice.

Advantage of Adipotide: It does not suppress appetite and acts directly on fat cells.

Advantages of GLP-1 drugs: Fewer potential side effects, especially less impact on the kidneys, suitable for long-term use.

Orlistat

Orlistat is a kind of fat absorption inhibitor, mainly by inhibiting the absorption of fat in the gastrointestinal tract to achieve weight loss, but often accompanied by gastrointestinal discomfort and other side effects.

Advantages of Adipotide: Adipotide does not affect food absorption, acts directly on fat cells, and may theoretically be more effective than Orlistat in reducing body fat.

Orlistat benefits: A long history of clinical use and a clear safety profile.

Phentermine (or other central nervous system appetite suppressant)

Phentermine helps with weight loss by suppressing appetite signals in the central nervous system, but may have cardiovascular side effects.

Advantages of Adipotide: Unlike Phentermine, Adipotide does not reduce appetite by affecting the brain or nervous system, so the risks associated with cardiovascular health are theoretically avoided.

Advantages of Phentermine: Short-term use of Phentermine has a strong appetite suppression effect on weight loss, and in some specific patients, the clinical effect is significant.

In SUMMARY:

The main advantage of Adipotide is its unique mechanism of action, which reduces local fat by destroying fat blood vessels without affecting appetite or gastrointestinal function, and may be effective in those who have difficulty with refractory fat reduction. However, it needs more trials to verify its effects and side effects than other long-proven weight loss drugs.