Solubility test of 1g MK677 in PEG300

PEG300 (polyethylene glycol 300) is a colorless, odorless liquid widely used in the pharmaceutical and chemical industries. It has good solubility, can dissolve a variety of hydrophilic and hydrophobic substances, and has good biocompatibility, so it is often used as a solvent or carrier. MK677 (Ibutamoren) stimulates the secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in the body by mimicking the action of Ghrelin. It has significant potential in the areas of muscle building, bone density enhancement and anti-aging, so it has received much attention. The aim of this experiment is to test the dissolution ability of PEG300 on MK677 and find a more effective dissolution method.

Experimental procedure

First prepare 1g of MK677 raw powder and solvent PEG300.

Initial test: Add 2ml PEG300

Add 2ml PEG300 to the measured MK677 raw powder. We can see that even without stirring, the MK677 powder has begun to dissolve.

Increase to 5ml

Next, we increased the solvent PEG300 to 5ml and used ultrasonic shock to assist the dissolution.

After ultrasonic shock assisted dissolution, we found that most of MK677 powder had been dissolved in PEG300, and only a small part was undissolved.

7ml PEG300

When the solvent PEG300 was increased to 7ml, only a small portion of MK677 remained undissolved.

8ml PEG300

We added another 1ml of solvent, adding a total of 8ml PEG300. By fully stirring, 1g MK677 was completely dissolved. The solution is transparent, which indicates that PEG300 is very soluble to MK677.

Experimental results and summary

This experiment verified the superior performance of PEG300 as MK677 solvent. 8ml of PEG300 completely dissolves 1g MK677, making it an efficient and convenient solution option. Compared to other solvents such as glycerin or olive oil, PEG300 has outstanding solubility and stability.

The highly efficient dissolution capacity of PEG300 provides a more flexible option for preparation, while ensuring the uniformity and transparency of the solution.

If you're interested in other compounds or solubility tests, stay tuned for more! Or follow us on Yutube to learn more. For the full video of the experiment, here.