Know MK677 Solubility in ethanol to do our own solution

Ethanol is a common organic solvent with strong solubility and can dissolve many polar and non-polar compounds. Because ethanol is widely used in many pharmaceutical formulations, it is also often used as a solvent. MK677 (Ibutamoren) is an oral growth hormone-secreting agonist widely used by Bodybuilders to help increase muscle growth, improve bone density, promote wound healing, and combat aging. MK677 is usually available in powder form, so its solubility is particularly important in experimental preparation, especially when developing oral dosage forms, where solubility directly affects bioavailability and efficacy. In this experiment, we will test the ability of ethanol to dissolve MK677 to evaluate its effectiveness as a solvent.

The purpose and significance of the experiment

The purpose of this experiment was to test the solubility of 1g MK677 in ethanol. Through this experiment, we can know whether ethanol is suitable for the dissolution of MK677 as a solvent, and whether it can be used as an effective solvent in the experiment. At the same time, we will discuss the influence of different concentrations of ethanol on the solubility, and further provide reference for the application of MK677.

Experimental procedure

Initial test: Add 2ml of ethanol

First, take 1g MK677 powder, add 1ml ethanol and stir. Since ethanol has a strong dissolving power, we expected to be able to see the powder dissolve. Using ultrasonic cleaner to help dissolve, we observed that most of the powder was dissolved and only part of the powder was undissolved. This suggests that ethanol may have a limited ability to dissolve MK677, or more solvent amounts may be required.

Increase solvent amount: Add to 4ml ethanol

We add 2ml ethanol again, now a total of 4ML has been added, and ultrasonic cleaner is used again to help dissolve.

After full mixing, MK677 powder was completely dissolved and the solution was clarified. This indicates that ethanol is very soluble to MK677.

Let stand and observe

Finally, we let the solution sit for 24 hours to observe any possible precipitation or stratification. The results of static observation showed that the solution did not stratify or precipitate significantly at rest, which means that the solubility of ethanol to MK677 is relatively stable.

Conclusion

This experiment showed that the solubility of ethanol to MK677 was good, and 1g MK677 raw powder could be completely dissolved by 4ml ethanol. Therefore, ethanol is a good choice when preparing the solution of MK677.