MK677 recipe with PEG400? Let test it Solubility first

PEG400 (polyethylene glycol 400) is a common organic solvent with strong solubility and good biocompatibility, so it is widely used in drug preparation. MK677 (Ibutamoren), as a non-peptide growth hormone secretion promoter, has been widely used in muscle building, anti-aging and related medical research fields. However, MK677 raw powder is sold in powder form, and if you want to make it into an easy-to-use solution form, you need to dissolve it in the appropriate solvent. The purpose of this experiment is to test the solubility of 1g MK677 in PEG400 and observe the state change during the dissolution process.

Experimental procedure

Initial test: Add 2ml PEG400

Place 1g MK677 powder in a clear glass container and add 2ml PEG400. During the dissolution of the powder, we use ultrasonic oscillators to assist the dissolution. However, we found that the MK677 powder was hardly dissolved at this time. So using PEG400 to dissolve MK677 may not be a good choice.

Increase dosage to 8ml

To improve the solubility, the amount of PEG400 was increased to 8ml and ultrasound was used to help them mix well. At this point, about half of the powder has dissolved. This means that there is not enough solvent, and we need to continue increasing PEG400.

PEG400 increased to 10ml

Subsequently, we increased PEG400 to 10ml and found that some powder was still undissolved. The picture is below. At this point, we decided to increase the PEG400 directly to 50ml.

Increase to 50ml

Continue to increase the dosage of PEG400 to 50ml. It was observed that a small amount of powder was still not completely dissolved. Therefore, in this experiment, we can see that 1g MK677 raw powder is partially dissolved in 50ml PEG400.

Experimental result

In this experiment, 8ml PEG400 could dissolve about half of 1g MK677 powder, but the solvent was eventually increased to 50ml, and the powder was still not completely dissolved. Therefore, to completely dissolve 1g MK677 powder, a larger dose of PEG400 is required. If the concentration of the solution is not very high, PEG400 can be selected as a solvent. On the contrary, DMSO, PEG300, etc. with better solubility for MK677 can be selected.

The advantage of PEG400 is its high safety and biocompatibility, which makes it suitable for use in preparations requiring milder solvents. In addition, PEG400's high viscosity and low volatility also give it an advantage in some long-acting preparations.

It should be noted that MK677 is dissolved using PEG400, but the larger dosage required may have an impact on the concentration, dosage and cost of the dosage form design in practical applications. Therefore, when using PEG400 as a solvent, it is necessary to weigh the relationship between dosage and dissolution efficiency according to actual needs.