May I use polypropylene glycol to make mk677 solution at home?

Polypropylene Glycol (PPG) is a common solvent due to its low toxicity, good solubility and wide application in the pharmaceutical industry. MK677 (Ibutamoren) is a commonly used muscle building supplement by bodybuilders, but in addition, mk677 acts similar to HGH and is also of great concern in the areas of fat metabolism and anti-aging. When you buy mk677 in powder form, how do you prepare it into a solution that is easy to use? Therefore, it is important to understand the solvents that can dissolve MK677. In this experiment, we will use polypropylene glycol to dissolve mk677 powder, so as to understand the solubility of polypropylene glycol to mk677 powder.

Experimental procedure

1. Preliminary test: Add 4ml polypropylene glycol

Add 1g MK677 powder to a clear glass container, followed by 4ml PPG. Observe the dissolution state: only a small part of the powder dissolves. This showed that 4ml PPG was not enough to dissolve 1g MK677, and we then added the solvent to 10ml.

2. Increase dosage to 10ml

In order to improve the solubility, the amount of PPG is directly increased to 10ml, and ultrasonic cleaner is used to assist the dissolution. At this time, it is found that the solution becomes more diluted, showing a more uniform milky liquid state. The results indicated that 10ml PPG was not sufficient to completely dissolve MK677.

3. Increase dosage to 50ml

After further increasing the amount of PPG to 50ml, use ultrasound to help dissolve and observe. At this time, the appearance of the solution becomes slightly transparent, but some of the powder is still undissolved.

Experimental result

The solubility of 1g MK677 in polypropylene glycol (PPG) is as follows:

1.4ml PPG: Only a small part of the powder is dissolved;

2.10ml PPG: partially dissolved, solution milky white;

3.50ml PPG: partially dissolved, not completely dissolved.

Conclusion

In this experiment, after adding 50ml polypropylene glycol, 1g MK677 powder did not show complete dissolution. This indicated that polypropylene glycol as the solvent of MK677 showed moderate solubility. Compared to more soluble solvents such as DMSO or PEG300, PPG may require a larger dosage to completely dissolve 1g MK677. However, PPG has low toxicity and good biocompatibility, and is widely used in oral and topical formulations, making it a relatively safe choice.

In addition, PPG has a higher viscosity, which can lead to a more time-consuming stirring and mixing process, but its high viscosity characteristics also give it a certain advantage in long-acting preparations. Due to the good stability of the solution after dissolution, PPG can be used in preparation scenarios where high stability and mild solvents are required.

It is important to note that PPG does not dissolve as efficiently as some highly effective solvents, so it may not be the best choice when a high concentration preparation is required. However, PPG is an ideal solvent for the preparation of low concentration solutions requiring high safety and wide use.