Mk677 recipe : how about the Solubility in grapeseed oil?

One of the most commonly used bodybuilding supplements, MK677 (Ibutamoren) has outstanding potential to promote muscle growth, improve sleep, enhance fat metabolism, and combat aging. If you have purchased mk677 raw powder, how can you configure it to be a MK677 solution that is easy to use? Understanding the solubility of MK677 powder in various common solvents will be very helpful. The solvent we're testing today is grapeseed oil.

Grape seed oil is a kind of plant extract, which is widely used in health care products and beauty fields because of its light weight, low irritant and high safety. Its fat-soluble properties make it one of the potential solvents for dissolving fat-soluble compounds. So, how soluble is MK677 powder in grapeseed oil? The answer lies in our next experiment.

Experimental procedure

Preliminary test: Add 2ml grapeseed oil

1g MK677 powder was added to a clear glass container, followed by 2ml grapeseed oil, and ultrasonic shock was used to help the powder dissolve.

Observation: MK677 powder was found to be almost undissolved after being evenly mixed. This suggests that 2ml of grapeseed oil is not effective at dissolving 1g MK677.

Increase dosage to 10ml

Because 2ml grapeseed oil did not have a good solubility for 1g MK677, we directly added grapeseed oil to 10ml, and also used ultrasound to help dissolve.

Observation: The mixture looks slightly diluted, but still cloudy, with a large amount of powder suspended in it and still precipitated particles at the bottom. This shows that 10ml of grapeseed oil is still not enough to completely dissolve 1g MK677.

Increase to 50ml test

In order to further verify the solubility of grapeseed oil, the amount of grapeseed oil was directly increased to 50ml, which was then left for static observation after ultrasonic oscillation.

Observation results: The solution was light yellow, still maintained turbidity, the particle distribution was uniform, but after standing, the bottom again appeared obvious precipitation. This shows that even in 50ml of grapeseed oil, MK677 is still not completely dissolved.

Summary of experimental results

The dissolution of 1g MK677 in different amounts of grapeseed oil is as follows:

1.1ml: The powder is almost completely undissolved, and the solution is milky white and cloudy.

2.10ml: The powder is partially dispersed, but not dissolved, and the solution is still cloudy;

3.50ml: The solution is still cloudy, obvious precipitation can be seen after standing, and MK677 cannot be completely dissolved.

Conclusion

In this experiment, 50ml grapeseed oil still could not completely dissolve 1g MK677 powder. This indicates that grapeseed oil has poor solubility for MK677 and can not achieve effective complete dissolution. In solution, MK677 powder can only be suspended in grapeseed oil and is not fully integrated with it. This may be because the molecular structure and physical properties of MK677 determine its low solubility in non-polar solvents, and grape seed oil, as a natural vegetable oil, although it has a certain fat solubility, but the solubility is limited.

Compared with other solvents (such as DMSO, PEG300), grapeseed oil is obviously not suitable as an ideal solvent for MK677. However, due to the natural nature and low irritability of grapeseed oil, if only a low concentration preparation in the form of suspension is required, it can still be considered as a carrier, but high concentration preparation requirements should be avoided.