How about the Solubility of RAD140 Powder in glycerin?

Glycerin, also known as glycerol, is a colorless transparent and viscous liquid with a slightly sweet taste, often used in food, medicine and cosmetics. As a common solvent, its unique consistency and hydrophilicity make it used to dissolve active ingredients in some cases. So, when glycerin is used to dissolve sarms RAD140, what will be the result of its dissolution?

The purpose of this experiment was to test the solubility of glycerol to 1g RAD140 powder and record the related phenomena and results.

Experimental procedure and observation

1. Initial test - 1ml glycerin

First, we absorb 1ml glycerol and add it to 1g RAD140 powder in a beaker. Due to the very high viscosity of glycerin, the straw is significantly hindered during operation. After pouring 1ml of glycerin into the sample, gently shake the beaker to observe the dissolution. It can be seen that the glycerin and RAD140 did not mix well, the powder mostly floated on the surface of the glycerin, and there was no sign of dissolution at all.

2. Increase to 2ml glycerin

We continue to add 1ml glycerin, bringing the total to 2ml, and try shaking and observing again. Due to the high viscosity of glycerin, this method of gradual addition of small amounts did not significantly improve the mixing state. The powder is still suspended or agglomerated, and the glycerin is covered with a layer on the surface, which does not fully integrate with the sample, let alone dissolve.

3. Increment to 10ml glycerin

To save time and observe more significant changes, we increased the total amount of glycerin directly to 10ml. After thorough stirring, it was found that the mixture of glycerol and RAD140 powder became finer and the dispersion of the sample was improved, but there was still no sign of dissolution. The mixture appears as a uniformly suspended paste rather than a transparent solution, indicating that glycerol has extremely limited ability to dissolve RAD140.

4. Ultimate Test - 50ml glycerin

To further confirm the solubility of glycerol, 50ml glycerol was directly added and fully mixed with 1g RAD140. After stirring, it was found that the homogeneity of the mixture was improved, but the solution was still in a suspended state, and there was no sign of dissolution. At this time, glycerol appears as a viscous liquid matrix, in which RAD140 powder is evenly dispersed, indicating that glycerol can be used as a mixing medium, but its solubility is very weak.

Experimental conclusion

Solubility result

In this experiment, RAD140 failed to dissolve even when 50ml glycerol was added, and only showed a dispersed state.

Although the high viscosity of glycerin allows it to suspend the powder well, it does not provide enough dissolution power to form a transparent solution.

Suitability of glycerol

Glycerol is not suitable as the main solvent for RAD140, especially if high concentrations of dissolution are required. Its viscosity may be helpful in mixing and dispersing, but it is not ideal for formulation design with high solubility requirements.

Summary and prospect

Through this experiment, we further confirmed the limitations of glycerol as a solvent. In future solvent screening or formulation optimization, it is possible to consider the formulation of a solvent with greater solubility, while using the viscous properties of glycerol as a stabilizer or adjuvant for the formulation. If you are interested in the dissolution test of other solvents, welcome to leave a message and exchange, we will see you next time!