LGD-4033 (Ligandrol) is a selective androgen receptor modulator (SARM) that is primarily used to help increase muscle mass, improve strength, and promote healthy bone density. It is commonly used in bodybuilding and strength training as an alternative with fewer side effects(the effect of suppress testosterone level) than steroids.

The following are some information about LGD-4033:

Mechanism of action: LGD-4033 acts primarily on muscle and bone by binding to androgen receptors, promoting protein synthesis and thereby increasing muscle and bone density.

Use: LGD-4033 is used to build muscle, increase strength and improve fitness, especially during fat loss or muscle recovery.

Dose: A common lgd4033 dose is 5-10 mg/day, and the cycle is usually 8-12 weeks, depending on personal goals and tolerance.

Results: Users report seeing noticeable changes in muscle growth, increased strength, and decreased body fat within a few weeks.

Is LGD-4033 safe?

The safety of LGD-4033 (Ligandrol) is the focus of discussion. Its side effects are small compared to steroids, but it is not a completely risk-free substance.

Safety for short term use

Human trials: Clinical trials have shown that LGD-4033 is relatively safe and well tolerated when used over a short period of time (approximately 12 weeks). Side effects reported by users are usually mild, including mild fatigue, headache, or dry mouth symptoms.

Less severe side effects: Unlike steroids, LGD-4033 has no serious liver toxicity or heart problems, and its hormonal fluctuations have less effect, so many people believe it is safer.

Effects on testosterone levels

Testosterone suppression: LGD-4033 can cause suppression of testosterone levels, especially when used in high doses and long cycles. Testosterone suppression can lead to low sex drive, fatigue, mood swings and other symptoms. As a result, many people undergo a recovery cycle (PCT) after use to help the body restore its natural testosterone levels.

Recovery Cycle (PCT) Recommendations: The use of PCT drugs (such as clomiphene or tamoxifen) is recommended to help restore testosterone levels in the body and alleviate potential long-term hormone suppression issues.

Risks of long-term use

Long-term effects are unclear: LGD-4033 has not been adequately studied in long-term clinical studies, so its long-term safety has not been fully validated. There may be unforeseen health risks associated with long-term use, such as potential effects on the liver, kidneys or heart.

Potential liver burden: Although LGD-4033 does not damage the liver as significantly as oral steroids, some users still report slightly elevated liver enzymes. Therefore, regular monitoring of liver function is recommended, especially during prolonged or high dose use.

Sum up

LGD-4033 is considered relatively safe in the short term, especially as it has fewer and milder side effects compared to steroids. But it's not completely risk-free, especially when it comes to testosterone suppression and potential long-term health effects. Users are advised to use it periodically, follow the appropriate dosage, and perform a recovery cycle (PCT) after use, while monitoring their health regularly.

How fast does LGD-4033 work?

LGD-4033 (Ligandrol) is known for its faster effects, especially in terms of building muscle and increasing strength. Most users will see noticeable changes within the first few weeks of use.

Initial use (1-2 weeks)

Strength boost: Many users feel a boost in strength during the first week, especially during weight training, with an increase in energy levels and endurance. Although muscle growth is not yet noticeable, an increase in strength is usually the first significant change.

Muscle pump feeling: After using LGD-4033, some people will feel the muscle "pump feeling" during training is stronger, and the muscle fullness and hardness are improved.

Mid-use (3-4 weeks)

Muscle gain: In weeks 3 to 4, users will begin to see significant muscle gain. LGD-4033 helps users gain lean muscle mass faster by promoting protein synthesis and nitrogen retention. The rate of muscle gain varies from person to person, but many users may see 3-5 pounds of muscle gain at this stage.

Fat loss: Although LGD-4033 is primarily used to build muscle, it also helps to reduce body fat, especially if calories are well controlled. This makes the body look firmer and more shaped.

Late use (5-8 weeks)

Significant muscle gain: Muscle gain becomes more significant with continuous use up to week 5-8. At this point, users typically gain 5-10 pounds or more of lean muscle mass, especially if their diet and training program is in place.

Strength gains continue: Strength gains also continue to increase with the cycle of use, and many users will find that their strength and training performance reaches new heights.

After the cycle (8-12 weeks)

Peak performance: By the end of the full 8-12 week cycle, users are usually able to experience significant muscle and strength gains. LGD-4033 helps maintain muscle mass and reduces catabolism, which makes it very effective in building muscle and reducing body fat.

Effect after recovery cycle (PCT)

Maintenance effect: Although some water loss may result in slight weight loss during the recovery of testosterone levels during PCT, users are usually able to retain most of their muscle and strength gains, especially if the PCT is appropriate and they continue to maintain a high-protein diet and intensity training.

Influencing factor

The combination of diet and training: The effect of LGD-4033 is closely related to the user's diet and exercise. If you eat a diet rich in high-quality protein, carbohydrates and enough calories, combined with high-intensity training, the effect is even more dramatic.

Individual differences: The rate at which the body responds to LGD-4033 will vary depending on the individual's genetic factors, metabolic rate, and muscle fitness.

Sum up

The effects of LGD-4033 can be seen in the first few weeks after use, with strength and muscle gain being the most significant changes. As the cycle continues, users will see significant lean muscle gain and body fat loss at 4-8 weeks. The combination of diet and training is crucial, and a proper recovery cycle (PCT) can also help to maximize the retention of muscle building effects.

Does LGD-4033 affect testosterone levels?

Yes, LGD-4033 (Ligandrol) affects the natural production of testosterone. Although it is a selective androgen receptor modulator (SARM) that primarily acts on androgen receptors in bones and muscles, it may still have a certain inhibitory effect on hormone balance in the body.

How does LGD-4033 affect testosterone levels?

Testosterone inhibition: LGD-4033 inhibits natural testosterone production in the body by binding to androgen receptors. When the body senses an external "androgen" signal, its own testosterone production decreases. This means that after using LGD-4033, testosterone levels in the body may decrease.

The dose is less than 5mg/ day

In 76 adult men who received low doses of LGD4033 with gradually increasing doses of 0.1mg,0.3mg and 1mg daily, a dose-dependent increase in muscle mass was observed over 21 days, while no significant side effects were observed over 21 days. A daily dose of 1mg of LGD4033 is enough to increase lean muscle mass by nearly 3 pounds.

According to the survey, the dosage used in bodybuilder is 5mg-10mg per day.

For beginners, the initial dose is about 2.5g per day.

A large amount of data shows that when the daily dose is no more than 5mg, basically no significant side effects, no significant testosterone inhibition.

The dose is higher than 5mg/day

At doses higher than or equal to 5 mg/day, LGD-4033 will have some degree of testosterone inhibition, but the degree may be mild.

The dose is higher than 10mg/day

The degree of inhibition is more pronounced when used at higher doses (such as 10 mg or more) or for longer cycles (8-12 weeks). Some users report a significant drop in testosterone levels at the end of the cycle, leading to fatigue, low libido and other symptoms.

Sum up

Using LGD-4033 at high doses for long periods of time does inhibit natural testosterone production. Users may experience symptoms such as fatigue and low sex drive. To reduce these effects, a recovery cycle (PCT) is recommended after use to help restore hormone levels in the body to normal levels.

How effective is LGD-4033 in combination with other supplements or SARMs?

LGD-4033 (Ligandrol) in combination with other supplements or SARMs is often referred to as "stacking" and can be used to improve muscle gain, fat loss, or strength. When combining supplements or different SARMs, you need to adjust them according to your goals and individual needs to maximize effectiveness while minimizing side effects. Here are the effects of LGD-4033 in combination with other common supplements or SARMs:

Use in conjunction with other SARMs

LGD-4033 + MK-677 builds muscle, improves strength and promotes recovery.

LGD-4033 is good at increasing muscle mass and strength, while MK-677 enhances muscle recovery and physical performance by promoting the secretion of growth hormone and IGF-1. The combination of the two is often referred to as a "muscle building stack" because MK-677 can further accelerate muscle growth while improving sleep and recovery and reducing fatigue after training.

Side effects: MK-677 has less effect on hormone levels, so it can effectively alleviate the hormone suppression problems caused by LGD-4033. However, long-term use still requires attention to PCT and testosterone recovery.

LGD-4033 + RAD-140 (Testolone) maximizes muscle growth and strength gains.

The RAD-140 is also a powerful SARM, often paired with the LGD-4033 for rapid muscle and strength improvement. The combination of the two can significantly increase lean muscle mass in the short term and improve training intensity.

LGD-4033 + S4 (Andarine) for muscle gain and fat loss.

S4 is often used for "clean muscle building" or "fat loss stacking" because it not only maintains lean muscle, but also helps reduce body fat. When stacked with LGD-4033, it enhances muscle contour and firmness while building muscle, making it suitable for those who wish to gain muscle but keep it low in fat.

LGD-4033 + Cardarine (GW501516) improves endurance, builds muscle and reduces fat.

Although Cardarine is not part of SARM, it mainly helps with fat loss by improving fat burning and metabolism in the body. When used in combination with LGD-4033, lean muscle growth can be achieved while accelerating fat loss. Cardarine will also significantly improve endurance and aerobic capacity, making it suitable for those who need to do long endurance training.

In combination with supplements

LGD-4033 + protein supplement

Protein is the key to building muscle. Using high-quality protein supplements (e.g., whey protein, plant protein, etc.) in combination with LGD-4033, it is possible to maximize protein synthesis and accelerate muscle repair and growth.

LGD-4033 + Branched Chain Amino Acids (BCAAs)

BCAAs help protect muscles during training, reduce muscle breakdown and speed recovery. Use with LGD-4033 can enhance muscle building and recovery effects, especially during intense training.

LGD-4033 + fish oil or Omega-3

Fish oil or Omega-3 supplements help reduce inflammation and protect joint and cardiovascular health. Since LGD-4033 is very helpful for strength improvement, combined with fish oil can reduce the burden on the joints and prevent inflammation caused by over-training.

LGD-4033 + vitamin and mineral supplement

Minerals such as vitamin D, zinc and magnesium are essential for maintaining hormone levels and bone health. Use with LGD-4033 can help maintain overall health and reduce the effects of hormone suppression.