Mestanolone is an anabolic steroid that belongs to the androgen class of drugs and has a chemical structure similar to testosterone. Its structure gives it strong anabolic properties with relatively few estrogenic side effects, so bodybuilders use it to build muscle. When stack it in combination with other anabolic steroids, Mestanolone helps enhance the overall cycle effect.

Chemical properties:

Chemical name: 17α-methyl-5α-androstane-3-one.

It is an anabolic steroid that is a methylated derivative of testosterone in chemical structure and has strong androgenic activity.

Main functions:

Promotes muscle growth: Mestanolone helps increase muscle mass by enhancing protein synthesis and nitrogen retention.

Improved strength and endurance: Athletes who use Mestanolone often report significant increases in strength and endurance.

Fat Reduction: Due to its metabolic effects, Mestanolone may also help reduce body fat percentage and enhance muscle line.

Application field:

In medicine, Mestanolone is sometimes used to treat conditions related to testosterone deficiency.

Mestanolone is primarily used in the bodybuilding community to enhance performance and improve muscle mass, especially during competition preparation.

What is the recommended dose of Mestanolone?

Mestanolone (methyldihydrotestosterone, 17alpha-methyl-DHT) is an oral synthetic androgen drug commonly used to improve strength, build body shape, or help maintain muscle stiffness and density during exercise and bodybuilding cycles. It is similar to Stanolone, but due to the addition of methyl groups, it is able to avoid rapid breakdown in the liver by being used in oral form.

General bodybuilder/athlete dosage: usually 10-30 mg/ day. Lower doses of Mestanolone (e.g. 10 mg) can help novice users gradually acclimate to its effects, while more experienced users may use higher doses (e.g. 20-30 mg/ day).

Dosage for women: Mestanolone is a powerful androgen that women generally avoid because it can cause serious masculine side effects (such as a rougher voice and increased body hair). If women choose to use it, 5 mg/ day or less is usually recommended to minimize the risk of side effects.

Cycle length: Mestanolone is usually used for 4-6 weeks. Due to its relatively high liver toxicity in its oral form, it is recommended not to exceed this cycle length to avoid placing an excessive burden on the liver.

Frequency: Mestanolone has a short half-life and usually needs to be taken once a day or in multiple doses to maintain a stable concentration of the drug in the blood.

How does Mestanolone affect muscle growth?

Mestanolone is an oral androgen drug with a mechanism of action similar to that of the testosterone metabolite DHT (dihydrotestosterone), acting primarily through strong androgenic effects. However, Mestanolone has a different effect on muscle growth than other anabolic steroids (e.g., testosterone).

The effect of Mestanolone on muscle growth

Promotes muscle stiffness and density

Mestanolone has a powerful androgenic effect that increases muscle stiffness and density. This is especially important for bodybuilders or weightlifters, especially during cutting or competition preparation, as Mestanolone helps muscles appear drier, stronger and reduce water retention.

Muscle mass: While Mestanolone does not significantly increase muscle volume, it improves the mass and contours of existing muscles, making them firmer and more detached.

Fat reduction and body fat control

Mestanolone reduces body fat by boosting metabolism and speeding up fat breakdown. This makes it excellent during the cutting cycle, especially when the user's goal is to lose fat and retain muscle. Its potent androgen properties can help maintain muscle mass while reducing body fat.

How it works: Mestanolone works by binding to androgen receptors to help promote fat burning while maintaining muscle. This makes it very effective when preparing for a competition or entering the final stage of the cutting cycle.

Increased strength and performance

Mestanolone improves strength and athletic performance, primarily by increasing aggression, concentration, and endurance. This is obviously helpful for athletes or strength trainers who need to increase their strength output in a short period of time, although the muscle volume increase will not be particularly significant.

Therefore, it is usually used for strength training and stages that require rapid strength improvement, rather than mass muscle building.

Does not significantly promote protein synthesis

Mestanolone has a weaker anabolic effect compared to other powerful anabolic steroids (e.g., testosterone,). Its main role is to affect the hardness of muscles through its androgenic effects. Therefore, Mestanolone does not increase muscle volume as significantly as testosterone , and is mainly used to increase lean muscle.

Antiestrogenic effect

Mestanolone does not convert to estrogen, so it protects against the side effects associated with water retention and gynecomastia. This makes it a powerful choice during cutting cycles or cycles with low moisture control, helping to maintain dry muscle condition and clear lines.

Best use of Mestanolone

Cutting cycle: Mestanolone is better suited for use during cutting cycles or competition preparation as it helps reduce body fat, maintain muscle stiffness and build strength without causing water retention.

Strength Boost: Because of its strong androgen effect, it is often used in the strength boost phase rather than for mass muscle gain. Mestanolone is the ideal choice for athletes who want to improve their strength and endurance rather than their size.

Competition preparation: In the run-up to bodybuilding competitions, Mestanolone helps to show clear muscle lines and avoid water retention while increasing strength and aggression.

How does Mestanolone work when stack with other steroids?

Mestanolone is commonly used in bodybuilding and strength training to improve muscle stiffness and density, as well as to enhance strength and performance. Since it has a reduced anabolic effect and is mainly used to increase lean muscle, if you want to use it to increase muscle circumference, you can stack it with some bulking steroids stack. When stack Mestanolone with other anabolic steroids, it can enhance the overall cycle effect.

Cutting cycle Mestanolone stack

Mestanolone is most commonly used during cutting cycles to help maintain muscle mass, reduce fat, and increase muscle stiffness. It usually stack with some low water retention steroids to ensure that the muscles are dry and have a strong sense of separation.

Mestanolone stack with Winstrol (Stanozolol)

Winstrol is a classic cutting steroid that helps maintain muscle mass and reduce body fat, especially during competition preparation.

How it works: Mestanolone provides a powerful androgen effect that increases muscle stiffness and dryness, while Winstrol helps maintain muscle bulk and separation.

Dosage: Mestanolone 10-30 mg/ day, Winstrol 30-50 mg/ day, cycle length 6-8 weeks.

Mestanolone stack with Anavar (Oxandrolone)

Anavar is a mild steroid that has a good fat-burning effect while maintaining lean muscle mass.

Combination effect: Anavar provides anabolic action to compensate for Mestanolone's weak anabolic deficiency, helping to maintain and improve muscle mass while losing fat.

Dosage: Mestanolone 10-30 mg/ day, Anavar 20-50 mg/ day, cycle length 6-8 weeks.

Muscle building cycle stack

While Mestanolone is primarily used in cutting cycles, it can also be used during muscle-building cycles, especially when paired with powerful anabolic steroids to maintain muscle stiffness and build strength.

Mestanolone stack with Testosterone (Testosterone)

Testosterone is the basic steroid in the muscle-building cycle and can significantly promote protein synthesis and muscle growth. The potent androgen action of Mestanolone enhances the effects of testosterone and reduces water retention.

The pairing effect: Mestanolone increases strength and muscle density, while testosterone is responsible for overall muscle growth.

Dose: Mestanolone 10-30 mg/ day, testosterone (propionate or enanthate) 250-500 mg/ week, cycle length 8-12 weeks.

Mestanolone stack with Deca-Durabolin (Nandrolone Decanoate)

Deca-Durabolin is a powerful anabolic steroid commonly used to increase muscle volume. Mestanolone helps reduce the water retention effects of Deca.

Pairing effect: Deca provides powerful anabolic effects to promote muscle growth, while Mestanolone helps maintain muscle stiffness and dryness through its androgenic effects.

Dosage: Mestanolone 10-30 mg/ day, Deca 200-400 mg/ week, cycle length 8-12 weeks.

Competition preparation

During competition preparation, stack Mestanolone with other powerful cutting steroids to minimize body fat and water retention while maintaining muscle line and stiffness.

Mestanolone stack with Trenbolone (Trenbolone Acetate)

Trenbolone is one of the most potent anabolic steroids, with strong fat-burning and muscle-retaining effects. It is often paired with Mestanolone and used to prepare for competitions.

How it works: Trenbolone helps reduce body fat and maintain lean muscle, while Mestanolone enhances muscle stiffness and dryness.

Dosage: Mestanolone 10-20 mg/ day, Trenbolone 75-100 mg/ day (in injection form), cycle length is 6-8 weeks.

Mestanolone stack with Masteron (Drostanolone)

Masteron is another common competition preparation steroid with potent androgen and anti-estrogen effects that help remove moisture and maintain muscle clarity.

Stack results: Mestanolone and Masteron, when used together, minimize water retention and help show a more separated and dry muscle line.

Dosage: Mestanolone 10-20 mg/ day, Masteron 200-400 mg/ week, cycle length 6-8 weeks.

Mestanolone is a steroid with a powerful androgenic effect that is often used in combination with other steroids to achieve specific training goals. It is best used during cutting cycles or competition preparation, increasing muscle hardness and density and reducing water retention. Common combinations include Winstrol, Anavar, testosterone, Deca-Durabolin, and Trenbolone. After the use cycle, PCT is also required to help restore natural testosterone production.