Humanin is an endogenous polypeptide composed of 24 amino acids that was first discovered in mouse models and later identified in humans as well. It is thought to have a variety of biological activities, especially in cell survival, metabolic regulation and neuroprotection plays an important role.

Why do people use Humanin?

Humanin is a small peptide that was first discovered in 1996 and has received a lot of attention for its potential role in cell survival, anti-aging, and metabolic regulation. Here's why people use Humanin and what benefits it may bring.

Anti-aging effect

Humanin is believed to have anti-aging properties. As we age, the cells in the body gradually decline, leading to an increased risk of aging-related diseases. Studies have shown that Humanin may slow the aging process by protecting cells from oxidative stress and apoptosis. This peptide helps defend against free radical damage by promoting the activity of antioxidant enzymes within cells, thus helping to maintain cell function and vitality.

Promote cell survival

Humanin also plays an important role in cell survival. Many studies have shown that Humanin can promote cell survival by inhibiting apoptosis (programmed cell death). This is especially important for neurons and other cells that are vulnerable to damage. For example, in models of neurodegenerative diseases such as Alzheimer's disease, Humanin has shown potential to protect neurons and reduce pathological damage. For this reason, many people use Humanin as a neuroprotectant to slow or prevent the degeneration of the nervous system.

Metabolic regulation

Humanin's regulatory effect on metabolism is also an aspect that has been widely concerned. Studies have found that Humanin can affect metabolic health by improving insulin sensitivity and promoting fatty acid oxidation. This makes Humanin a possible anti-diabetes and anti-obesity treatment option. For those at risk of metabolic syndrome, obesity, or type 2 diabetes, Humanin may offer a beneficial intervention.

Cardiovascular health

Cardiovascular disease is one of the leading causes of death worldwide. Humanin is believed to help improve heart health. Some studies have shown that Humanin is able to enhance the function of the heart by reducing oxidative stress on heart cells and promoting the health of blood vessel endothelial cells. These properties may reduce the risk of cardiovascular events, so many fitness enthusiasts and older adults have started using Humanin to improve their heart health.

Anti-inflammatory effect

Chronic inflammation is strongly linked to the development of several diseases, including heart disease, diabetes, and certain cancers. Humanin has anti-inflammatory properties that can reduce inflammation by regulating the immune response and inhibiting the release of inflammatory mediators. This makes Humanin a potential anti-inflammatory treatment option for those facing inflammation-related health issues whose use could bring positive results.

Improve athletic performance

In the bodybuilding and sports community, the use of Humanin has also received attention. Due to its regulatory effect on metabolism and protective effect on cell survival, Humanin is believed to be able to improve athletic performance and recovery. Some athletes and fitness enthusiasts may use Humanin to improve strength, endurance, and overall athleticism. In addition, Humanin may help speed up muscle recovery and reduce fatigue and muscle soreness after exercise.

As an anti-aging supplement

Due to the increasing concern for health and longevity, many people look to Humanin as an anti-aging supplement. In some health care products, Humanin is added to help users improve overall health, enhance vitality and slow the aging process. This trend is gaining popularity among health-conscious consumers, driving the rapid development of Humanin-related research and products.

Conclusion

In summary, people use Humanin for a variety of reasons, including anti-aging, cell survival, metabolic regulation, cardiovascular health, anti-inflammatory effects, enhancing exercise performance, and as a supplement. Although Humanin's research is ongoing, there is already scientific evidence of its potential importance in health and disease management.

Does Humanin help with Alzheimer's disease?

Humanin is a small peptide that has attracted increasing attention in Alzheimer's disease (AD) research in recent years. Here are a few ways Humanin could help with Alzheimer's disease:

Neuroprotective effect

Studies have shown that Humanin has neuroprotective properties that can help protect neurons from oxidative stress and apoptosis. In Alzheimer's disease, the damage and death of neurons is a major feature of the disease's development. This protective effect of Humanin may help delay the degeneration of nerve cells.

Reduce inflammation

Alzheimer's disease is closely related to neuroinflammation. Humanin has shown anti-inflammatory effects and is able to inhibit the release of inflammatory mediators, thereby reducing the inflammatory response of the nervous system. This property may play an important role in the treatment of Alzheimer's disease, as controlling inflammation helps slow down the disease process.

Improve mitochondrial function

The decline of mitochondrial function is considered to be one of the pathogenesis of Alzheimer's disease. Humanin may help improve energy metabolism in cells by promoting the health and function of mitochondria. Improving mitochondrial function can help protect neurons and slow the progression of Alzheimer's disease.

Inhibit amyloid deposition

A distinctive feature of Alzheimer's disease is the abnormal accumulation of amyloid beta (Aβ) protein, which is strongly associated with damage to nerve cells. Some studies have found that Humanin can inhibit the neurotoxicity caused by Aβ to A certain extent, thereby protecting nerve cells from its damage. This mechanism provides a theoretical basis for Humanin's potential therapeutic role in Alzheimer's disease.

Improve cognitive function

Some early animal studies and clinical studies suggest that Humanin may help improve cognitive function. In animal models treated with Humanin, improvements in memory and learning were shown. This finding hints at Humanin's potential to delay cognitive decline associated with Alzheimer's disease.

Regulate insulin sensitivity

The study also found that Humanin was able to improve insulin sensitivity, which is often characterized by insulin resistance in Alzheimer's patients. By improving the function of insulin, Humanin may help reduce the risk of Alzheimer's disease.

Conclusion

Although research on the specific mechanisms and clinical effects of Humanin in the treatment of Alzheimer's disease is still ongoing, the available research results show that Humanin has certain neuroprotective, anti-inflammatory and metabolic improvement effects, which may have a positive impact on the prevention and treatment of Alzheimer's disease.