IGF-ILR3 (Insulin-like Growth Factor Binding Protein 3) is a protein synthesized primarily in the liver and belongs to the IGF-binding protein family. Igf-ilr3 plays an important regulatory role in growth hormone (GH) and insulin-like growth factor (IGF) signaling, it plays an important role in muscle cell growth and metabolism.
Basic information about IGF-ILR3:
Mechanism of action:
IGF-ILR3 regulates its biological activity mainly by binding IGF-1, affecting cell growth, proliferation and differentiation. IGF-ILR3 plays an important role in cell growth and metabolism by regulating IGF-1 signaling by limiting its availability.
Purpose:
Research Uses: IGF-ILR3 is widely used to study biological processes such as growth, metabolism, tumor and aging.
Potential therapies: Because IGF-ILR3 plays a regulatory role in a variety of physiological and pathological processes, its potential in the treatment of related diseases such as diabetes, tumors, and growth disorders is being investigated.
Side effects:
There have been no clear documented side effects with widespread use of IGF-ILR3. Because of its effect on cell proliferation, it should be used with caution.
How does IGF-ILR3 work?
Igf-ilr3 (Insulin-like growth factor - insulin-like growth factor receptor 3) is an important component of the insulin-like growth factor (IGF) signaling pathway. Its main function is to regulate cell growth, proliferation and survival. The following are the main aspects of IGF-ILR3's working mechanism:
Release and binding of IGF
Source of IGF: IGF-1 (insulin-like growth factor 1) is usually synthesized by the liver but can also be produced by other cells such as muscle cells. Its synthesis is usually stimulated by growth hormone (GH).
Binding to IGF-ILR3: IGF-1 binds to IGF-ILR3 (also known as the IGF-1 receptor), forming a complex that initiates downstream signaling.
Receptor activation
Receptor conformation change: After IGF-1 binds to IGF-ILR3, the conformation of the receptor changes. This change enhances the activity of endogenous tyrosine kinase of the receptor, leading to phosphorylation of the receptor itself.
Downstream signaling
Activation Signaling pathway: Phosphorylated IGF-ILR3 receptors recruit and activate a variety of signal transduction molecules, including:
IRS (insulin receptor substrate) : IRS protein is phosphorylated by the receptor and binds to PI3K (phosphatidylinositol 3-kinase) to activate the downstream AKT (protein kinase B) pathway. AKT plays an important role in cell proliferation and survival.
MAPK (mitogen-activated protein kinase) pathway: IGF-1 can also activate the RAS/MAPK pathway, which is involved in cell proliferation, differentiation, and survival.
Cellular reaction
Promote cell proliferation and growth: IGF-1 promotes cell growth, proliferation and survival by activating AKT and MAPK signaling pathways. It helps the growth of muscle cells, bone cells and other cells.
Inhibition of apoptosis: IGF-1 also promotes cell survival by inhibiting apoptosis (programmed cell death).
Regulate metabolism
Enhanced glucose absorption: IGF-1 enhances glucose uptake by cells and regulates metabolic processes through the AKT pathway.
Promotes amino acid transport: IGF-1 also promotes the transport of amino acids into cells, further supporting protein synthesis.
Interaction with other factors
Synergies with other growth factors: The action of IGF-1 may interact with other growth factors (such as insulin, GH, etc.) to jointly regulate cell growth and metabolism.
Sum up
IGF-ILR3 (IGF-1 receptor) activates downstream signaling pathways by binding IGF-1 to promote cell proliferation, survival, and metabolism. This mechanism plays an important role in muscle growth, bone development and other physiological processes. Understanding the mechanism of IGF-ILR3 is important for studying the role of growth factors and their role in disease.
What is the relationship between IGF-ILR3 and IGF-1?
The relationship between IGF-ILR3 (also known as IGF-1R, that is, the insulin-like growth factor-1 receptor) and IGF-1 (insulin-like growth factor-1) is a receptor-ligand relationship, that is, IGF-ILR3 is a receptor for IGF-1, which is specifically responsible for receiving and conducting IGF-1 signals. Here is a detailed description of their relationship:
Ligand binding to receptor
IGF-1 is a ligand: IGF-1 is a polypeptide hormone with a structure similar to insulin. It is secreted by the liver and can also be produced locally in tissues such as muscles. The main function of IGF-1 is to promote cell growth, differentiation and metabolism, especially muscle and bone growth.
IGF-ILR3 is a receptor: IGF-ILR3 is a transmembrane receptor on cell membranes and belongs to the tyrosine kinase receptor family. It is a specific receptor that IGF-1 recognizes and binds to on the surface of target cells. When IGF-1 binds to IGF-ILR3, it activates a series of downstream signaling pathways that produce a cellular response.
Signal transduction mechanism
Binding activation: When IGF-1 binds to IGF-ILR3, the IGF-ILR3 receptor undergoes a conformational change that activates its internal tyrosine kinase activity, the receptor is phosphorylated, and the intracellular signaling pathway is activated.
Activation of downstream signaling pathways: IGF-ILR3, when activated, regulates cell function through two main signaling pathways:
PI3K/AKT pathway: It mainly regulates cell survival, metabolism and growth.
RAS/MAPK pathway: mainly promotes cell proliferation and differentiation.
These signaling pathways work together to regulate cell proliferation, metabolism, repair and growth.
Physiological function
Promote cell growth and proliferation: The binding of IGF-1 and IGF-ILR3 mainly promotes cell growth and proliferation. In muscle cells, for example, they work together to promote the enlargement and regeneration of muscle.
Regulation of metabolism: IGF-1 also influences glucose uptake, amino acid transport, and protein synthesis through the IGF-ILR3 receptor, thereby regulating energy metabolism.
Anti-apoptotic effect: IGF-1 inhibits apoptosis through IGF-ILR3 and protects cells from damage, especially under stress.
Similarities between IGF-1 and insulin
IGF-1 and insulin are structurally similar in that they can bind to their respective receptors (IGF-1R and insulin receptor) and activate similar signaling pathways. However, IGF-1 mainly regulates cell growth and proliferation, while insulin is more focused on regulating metabolism, especially glucose metabolism. Although the two have a synergistic effect, their biological functions and signaling pathways have certain specificity.
Negative feedback regulation
Signaling between IGF-1 and IGF-ILR3 is also controlled by a variety of regulators, such as IGF-binding proteins (IGFBPs), which regulate the availability and intensity of action of IGF-1. GH (growth hormone) promotes the synthesis of IGF-1, and IGF-1 inhibits GH secretion through negative feedback to maintain homeostasis.
Sum up
IGF-1 is a ligand for IGF-ILR3 (IGF-1 receptor), and the relationship between them is a typical ligand-receptor relationship. By binding to IGF-ILR3, IGF-1 activates intracellular signaling pathways, promoting cell growth, proliferation, metabolism and anti-apoptosis. This mechanism plays an important role in muscle growth, bone development and overall growth and development, and is also the focus of bodybuilders.
Product Name:IGF-ILR3
Other Name:Insulin-like Growth Factor Binding Protein 3
Purity:98% HPLC
Packing:1mg/vial; 10vials/box
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