Tesamorelin is a synthetic growth hormone releasing hormone (GHRH) analogue that is primarily used to stimulate the secretion of growth hormone. It is approved to treat excess accumulation of abdominal fat associated with HIV, helping to reduce fat accumulation.

How does Tesamorelin work?

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analogue that is primarily used to promote growth hormone secretion. Its mechanism of action involves the following aspects:

Promote the release of growth hormone

GHRH receptor activation: Tesamorelin stimulates the pituitary gland to secrete growth hormone (GH) by binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland.

Pulse release: Growth hormone is usually released in pulses, and the action of Tesamorelin can increase the frequency and intensity of these pulses, thereby increasing the overall level of growth hormone in the body.

Downstream signaling

Activation of the JAK2/STAT5 pathway: Upon release of growth hormone, signals are transmitted in target cells through the JAK2/STAT5 signaling pathway. This pathway plays a role in multiple cell types, including muscle cells and fat cells.

Promotes IGF-1 synthesis: Growth hormone stimulates the liver and other tissues to synthesize insulin-like growth factor-1 (IGF-1), which is an important growth factor involved in regulating cell proliferation, differentiation, and metabolism.

Promote fat metabolism

Reduced body fat: Tesamorelin use has been associated with improved fat metabolism, especially reduced abdominal fat. In the process of increasing growth hormone and IGF-1 levels, Tesamorelin promotes fat oxidation and reduces fat storage.

Improve body composition

Increase lean body mass: By promoting protein synthesis and muscle growth, Tesamorelin helps improve body composition, increase lean body mass (muscle mass) and reduce body fat.

Effects on glucose metabolism

Enhanced insulin sensitivity: Tesamorelin may indirectly improve insulin sensitivity by improving fat metabolism and body composition, contributing to blood sugar control.

Improve physiological function

Boosts energy levels and fitness: By promoting growth hormone secretion, Tesamorelin may help improve energy levels, athletic performance, and overall body function.

Sum up

Tesamorelin promotes the release of growth hormone by activating growth hormone releasing hormone receptors, thereby enhancing IGF-1 synthesis and improving fat metabolism and body composition. Its mechanism of action makes it an important application in the treatment of growth hormone deficiency and related metabolic disorders, as well as in the enhancement of fitness and athletic performance.

How do Bodybuilders use Tesamorelin?

Tesamorelin is used by bodybuilders primarily to promote the release of growth hormone, thereby increasing muscle mass, improving body composition and enhancing athletic performance. Here are some common ways that bodybuilders use Tesamorelin:

Dosage and mode of administration

Dose: The usual dose of Tesamorelin is generally 1-2 milligrams (mg), usually given once a day or divided into two injections. The dosage can be adjusted according to individual goals and reactions.

Method of administration: Tesamorelin is usually administered by subcutaneous injection, usually in the abdomen, legs or lower skin of the upper arm.

Cycle

Cycle scheduling: Bodybuilders may use Tesamorelin during their training cycle, which is typically 8-12 weeks. Some people may choose to use it in combination with other enhancing supplements (such as growth hormones, steroids, etc.) for best results.

Rest period: After the end of the use cycle, a certain rest period is recommended to prevent the body from producing tolerance and maintenance effects.

Optimum service time

Pre - and post-training use: Some bodybuilders choose to inject Tesamorelin before or after training to improve training performance and promote recovery. Post-training use can enhance muscle repair, while pre-training use may improve energy and endurance.

Fasting state: Some users recommend injecting Tesamorelin on an empty stomach to enhance absorption and effect.

Use in combination with other substances

Additive use: Bodybuilders often combine Tesamorelin with other substances that enhance muscle growth and recovery, such as:

Growth hormone: Use in combination with growth hormone may have a synergistic effect, further promoting muscle growth and fat loss.

Steroids: Used in combination with anabolic steroids, can enhance the effects of strength and weight gain.

Amino acid and protein supplements: Help support the effects of Tesamorelin and promote muscle growth.

Monitoring effect and adjustment

Effect monitoring: During the use of Tesamorelin, bodybuilders should regularly monitor the effects, including muscle growth, recovery rate and overall athletic performance. If side effects or unsatisfactory effects are found, the dosage or use method can be adjusted as needed.

Side effect management: Be aware of possible side effects, such as injection site reactions, headaches or edema, and promptly communicate with a professional.

Sum up

The use of Tesamorelin by bodybuilders mainly involves dose management, injection mode, cycle scheduling, and combination with other supplements. Understanding how to use Tesamorelin properly can help them maximize its effects on muscle growth and athletic performance while paying attention to safety.

Do Bodybuilders use Tesamorelin to help build muscle?

Yes, bodybuilders do use Tesamorelin to help build muscle. Tesamorelin is a growth hormone-releasing hormone (GHRH) analogue that stimulates the pituitary gland to secrete more growth hormone, thereby promoting muscle growth and recovery. Here are a few key reasons why bodybuilders use Tesamorelin to build muscle:

Increase growth hormone levels

Promotes muscle synthesis: Tesamorelin stimulates the release of growth hormone in the body, which helps increase protein synthesis, thereby promoting muscle growth and recovery.

Increased IGF-1 levels: An increase in growth hormone also causes the liver to secrete insulin-like growth factor-1 (IGF-1), an important growth factor that further promotes the proliferation and repair of muscle cells.

Improve body composition

Reduction of body fat: Tesamorelin can also promote fat metabolism, especially the reduction of abdominal fat. This helps improve body composition and makes muscles more pronounced and firm.

Increase lean body mass: By promoting muscle growth and reducing fat, Tesamorelin helps increase lean body mass (muscle mass) to fat ratio.

Improve resilience

Accelerated recovery: Tesamorelin contributes to the rapid recovery of muscles after high-intensity training, reducing post-training fatigue and enabling bodybuilders to perform high-intensity training more frequently.

Enhance athletic performance

Improve strength and endurance: As muscle mass increases, bodybuilders often find that their strength and endurance also improve, which allows them to be more effective in training.

Stack use

Stack with other supplements: Many bodybuilders stack Tesamorelin with other supplements, such as growth hormones, steroids, or amino acids, for a more significant muscle building effect.

Sum up

Tesamorelin is widely used by bodybuilders to promote the secretion of growth hormone, which increases muscle growth and recovery. By improving body composition, reducing body fat and accelerating recovery, Tesamorelin helps bodybuilders achieve better training results and physical goals. However, it is important to pay attention to the dosage and cycle schedule when using, and consider its potential side effects.